This may work:
How can you stop Windows XP from launching program CDs?
* Click Start, click Run, type GPEDIT.MSC to open Group Policy in the Microsoft Management Console.
* Double-click Computer Configuration, double-click Administrative templates, double-click System, and then click Turnoff autoplay.
* The instructions on your screen describe how to configure this setting. Click Properties to display the setting dialog.
* Click Enabled, and choose CD-ROM drives, then click OK, to stop CD autoplay.
This setting does not prevent Autoplay for music CDs.
or this
If you disable "autoplay" via Tweak UI (Tweak UI -> My Computer -> Autoplay -> Drives -> UnCheck Drive Letters), it will disable "autorun".
Tweak UI places a "Do not AutoRun" entry into the registry for each drive un-selected; however it remains turned on overall (so if you installed a new drive it would be enabled on that by default).
or reg edit
[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Servic es\Cdrom]
"AutoRun"=dword:00000000
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