I have a Harmony 650, been using it for a few years. No complaints, even the missus can use it.
I dont think you can go wrong with a Harmony, they are the leaders in the Universal remote field and I have never come across anyone with issues. I set mine up plugged in to the computer, loaded 4 different devices on it and haven't had to touch it since.
Even their cheapies are good, I bought one a few years back just out of interest. I ended up giving it to mate who still uses it.
Edit : Interesting to see the 650 is still current , the one my mate had is the 350, also still being sold.
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