I know very little about them (even though my son has one), but when I setup a wireless network for some friends, and they asked about their son being able to use his DS on it, I did a bit of searching online.
What I found was that it doesn't support WPA, only WEP. So unless you're in the middle of nowhere, where there's no chance of anyone receiving your wireless network, I wouldn't.
There's a wireless USB dongle thingy available, and they had one of those, but I wasn't able to get it working on their desktop machine in the time that I had available. But I did set it up temporarily on my notebook, to see if it'd work (which it did).
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